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SpermMar™ IgG

Test for the detection of anti-sperm antibodies

SpermMar™ IgA and SpermMar™ IgG are rapid, easy-to-use tests for the detection of anti-sperm antibodies in semen and serum.
Anti sperm antibodies (ASA) are produced when the blood-testis barrier is disrupted by obstruction, infection or traumatism. Immunoglobulines of the IgG class are usually present in both serum and semen, and the IgG antibodies attach to the spermatozoa. ASA of the IgA class are secreted by the accessory sex glands and are found in semen only. ASA of the IgG class may be detected in seminal plasma, but there is usually no free IgA in seminal plasma. Anti sperm antibodies of the IgA class almost never occur without IgG antibodies.
In case more than 40% of motile spermatozoa present ASA of the IgG class, complementary testing for IgA antibodies is advisable.
The immunological factor reduces the probability of spontaneous conception, and this is particularly true when ASA of the IgA class are also present.

SpermMar™ IgG has an 18 month shelf life from date of produce.

SpermMar™ IgG has been CE marked according to the specifications set forth in the European Medical Device Directive 98/79/EC.

We recommend to watch our demonstration video of the SpermMar Test IgG:
https://www.youtube.com/watch?v=pPpV_SHbKjI

Product order codes

SPMG_S SpermMar IgG singles - 50 tests
SPMG_C SpermMar IgG complete - 50 tests
SPMG_P Positive controls for SpermMar IgG
SPMG_N Negative controls for SpermMar IgG


Literature


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Tennakoon V., Weerasekera DS., Yasawardene SG., Successful pregnancy outcomes following in-vitro fertilization in infertile couples with high levels of antisperm antibodies, Sri Lanka Journal of Obstetrics and Gynaecology (2010),Vol.32,pp.47-48

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Hossain A., Islam N., Schultz N., Pratt D., Madanes A., Evidence of a Relationship Between Age of the Infertile Patient and the Prevalence of Antisperm Antibody (ASA), Fertility and Sterility (2008),Vol.84,No.S1,pp.S457

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Chiu W.W-C., Chamley L.W., Human seminal plasma prolactin-inducible protein is an immunoglobulin G-binding protein, Journal of Reproductive Immunology (2003),Vol.60,pp.97-111

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Tomsu M., Sharma V., Miller D., No evidence for a decreased fertilizing potential after in-vitro fertilization using spermatozoa from polyzoospermic men, Human Reproduction (2002),Vol.17,No.7,pp.1856-1862

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Verheyen G., Tournaye H., Laurier K., Devroey P., Van Steirteghem A., Auto-controlled study on in-vitro fertilization performance with 'antibody-free' spermatozoa selected by immunobead adsorption from semen of patients with anti-sperm antibodies, Human Reproduction (1994),Vol.9,No.6,pp.1119-1126

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Kay D.J., Boettcher B., Comparison of the SpermMar Test with Currently Accepted Procedures for Detecting Human Sperm Antibodies, Reprod. Fertil. Dev. (1992),Vol.4,pp.175-81

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Resources

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